| Powder: | Yes |
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| Customized: | Non-Customized |
| Certification: | GMP, HSE, ISO 9001, USP, BP |
| Suitable for: | Elderly, Children, Adult |
| State: | Powder |
| Purity: | >99% |
| Samples: |
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| Customization: |
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Audited Supplier 
| Product Name | Supply High Quality CAS 50264-69-2 Treatment of Cancer Lonidamine |
| Appearance | White powder |
| Molecular formula | C15H10Cl2N2O2 |
| Molecular weight | 321.16 |
| Keywords | Powder Lonidamine,Price Lonidamine ; Pure Lonidamine |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
What is Lonidamine ?
Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH).
Function of Lonidamine
1. Lonidamine does not affect cell proliferation, but mainly acts on the energy metabolism of cells. It reduces the glycolysis of tumour cells by altering the mitochondrial ultrastructure of tumour cells, inhibiting the activity of hexokinase that binds to mitochondria, and affects the expression of apoptosis-related proteins, inhibiting the oxygen consumption of malignant cells to achieve the purpose of killing tumour cells. It can be used in the treatment of various tumours such as breast cancer, prostate cancer, lung cancer and brain tumours, etc. It is being increasingly studied and applied because of its broad anti-cancer spectrum and low side effects.
2. Lonidamine can be used for various tumours such as breast, prostate and lung cancers and brain tumours. Also a spermicidal agent.
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Audited Supplier 
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