Powder: | Yes |
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Customized: | Non-Customized |
Certification: | GMP, HSE, ISO 9001, USP, BP |
Suitable for: | Elderly, Children, Adult |
State: | Powder |
Purity: | >99% |
Samples: |
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Customization: |
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Product Name | Supply High Quality Clotrimazole CAS 23593-75-1 for Anti-Fungal |
Appearance | White powder |
Molecular formula | C22H17ClN2 |
Molecular weight | 344.84 |
Keywords | Clotrimazole, Material Clotrimazole; Pure Clotrimazole |
Shelf Life | 24 months when properly stored |
Storage | Keep in a cool, dry, dark location |
What is Clotrimazole
Clotrimazole is an artificially synthetic azo le antifungal agent with inhibitory effect on a variety of pathogenic fungi. It is also able to directly kill the fungi at high concentration. Clotrimazole, through interfering with cytochrome P450 activity, inhibits the biosynthesis of the fungal ergosterol and other steroids; cause damage of the fungal cell membrane and change its permeability, causing the leakage of many kinds of important material in the cell; it can also inhibit the biosynthesis of the fungal triglyceride and phosphor-lipid; the product can still inhibit the activity of oxidase and peroxidase, causing the over-accumulation of peroxides in the cell, causing the degeneration and necrosis of the fungal subcellular structures. Clotrimazole has broad-spectrum antifungal activity with excellent anti-fungal activity against Epidermophyton, Trichophyton, aspergillosis, coloring fungi, Cryptococcus and Candida species. It also has certain antifungal effect against sporothrix schenckii,blastomycosis dermatitidis, Blastomyces coccidioides as well as Histoplasma.
1. Clotrimazole (Lotrimin, Mycelex, etc.) is a synthetic imidazole agent. It acts by altering cell membrane permeability. It inhibits the growth of most dermatophyte species, yeast and Malassezia furfur.
2. Clotrimazole formally also is an imidazole derivative because of the presence of an imidazole ring in its structure. It is believed that, like miconazole, econazole, and other "pure" representatives of the imidazole class, it also inhibits the biosynthesis of ergosterin in the cytoplasmatic membrane of fungi.
3. Clotrimazole is an anti-mycotic, for the treatment of superficial and deep mycotic infections, etc.
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